Within the framework of public policy to promote MSMEs and their internationalization, and with the aim of implementing strategies to encourage their development and growth—especially in this context of economic recovery following the COVID-19 pandemic—the Ministry of Production (PRODUCE) has proposed the significant challenge of building an evidence-based information system. This system will incorporate a set of indicators to serve as a reference for guiding the design of various programs and actions, with the goal of impacting the productive development of MSMEs.